Introduction
Wacom CTH-460 Bamboo Pen & Touch is a fairly easy device to disassemble, requiring only a Phillips #000 screwdriver and tweezers or similar tool to pry adhered and clipped elements.
The only fragile elements are flex cables connecting the touch digitizer to the mainboard.
If you plan on replacing the USB cable, please note that the USB cable is soldered to the mainboard.
Tools
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Use spudger or other prying tool to open the tablet.
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The clips are located all around the perimeter of the tablet
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Conclusion
To reassemble your device, follow these instructions in reverse order.